Article

Muscle Fibroblasts and Stem Cells Stimulate Motor Neurons in An Age and Exercise-Dependent Manner

2024-08-19

Abstract excerpt

Exercise preserves neuromuscular function in ageing through unknown mechanisms. Skeletal muscle fibroblasts (FIB) and stem cells (MuSC) are abundant in skeletal muscle and reside close to neuromuscular junctions, but their relative roles in motor neuron maintenance remain undescribed. Using direct co-cultures of embryonic rat motor neurons with either human MuSC or FIB, RNA sequencing revealed profound differentia...

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Literature Corpus work: 2e938aca-622b-5179-80d7-7bc099a01a42
DOI: 10.1101/2024.08.19.608387

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