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Article

Population genetics of immune-related multilocus copy number variation in Native Americans.

Journal of the Royal Society, Interface - 1 Mar 2017

Zuccherato Luciana W, Schneider Silvana, Tarazona-Santos Eduardo, Hardwick Robert J, Berg Douglas E, Bogle Helen, Gouveia Mateus H, Machado Lee R, Machado Moara, Rodrigues-Soares Fernanda, Soares-Souza Giordano B, Togni Diego L, Zamudio Roxana, Gilman Robert H, Duarte Denise, Hollox Edward J, Rodrigues Maíra R

Abstract excerpt

While multiallelic copy number variation (mCNV) loci are a major component of genomic variation, quantifying the individual copy number of a locus and defining genotypes is challenging. Few methods exist to study how mCNV genetic diversity is apportioned within and between populations (i.e. to define the population genetic structure of mCNV). These inferences are critical in populations with a small effective...

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Identifiers

PMID: 28356540
DOI: 10.1098/rsif.2017.0057
PMCID: PMC5378149

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