Article
Strain-specific estimation of epidemic success provides insights into the transmission dynamics of tuberculosis.
Scientific reports - 28 Mar 2017
Rasigade Jean-Philippe, Barbier Maxime, Dumitrescu Oana, Pichat Catherine, Carret Gérard, Ronnaux-Baron Anne-Sophie, Blasquez Ghislaine, Godin-Benhaim Christine, Boisset Sandrine, Carricajo Anne, Jacomo Véronique, Fredenucci Isabelle, Pérouse de Montclos Michèle, Flandrois Jean-Pierre, Ader Florence, Supply Philip, Lina Gérard, Wirth Thierry
Abstract excerpt
The transmission dynamics of tuberculosis involves complex interactions of socio-economic and, possibly, microbiological factors. We describe an analytical framework to infer factors of epidemic success based on the joint analysis of epidemiological, clinical and pathogen genetic data. We derive isolate-specific, genetic distance-based estimates of epidemic success, and we represent success-related time-dependent...
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