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Article

Prefrontal gray matter volume mediates genetic risks for obesity.

Molecular psychiatry - 1 May 2017

Opel N, Redlich R, Kaehler C, Grotegerd D, Dohm K, Heindel W, Kugel H, Thalamuthu A, Koutsouleris N, Arolt V, Teuber A, Wersching H, Baune B T, Berger K, Dannlowski U

Abstract excerpt

Genetic and neuroimaging research has identified neurobiological correlates of obesity. However, evidence for an integrated model of genetic risk and brain structural alterations in the pathophysiology of obesity is still absent. Here we investigated the relationship between polygenic risk for obesity, gray matter structure and body mass index (BMI) by the use of univariate and multivariate analyses in two large,...

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PMID: 28348383
DOI: 10.1038/mp.2017.51

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