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Is the hypothesis of preimplantation genetic screening (PGS) still supportable? A review

27 Mar 2017

Abstract excerpt

The hypothesis of preimplantation genetic diagnosis (PGS) was first proposed 20 years ago, suggesting that elimination of aneuploid embryos prior to transfer will improve implantation rates of remaining embryos during in vitro fertilization (IVF), increase pregnancy and live birth rates and reduce miscarriages. The aforementioned improved outcome was based on 5 essential assumptions: (i) Most IVF cycles fail...

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PMID: 28347334
DOI: 10.1186/s13048-017-0318-3

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