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Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

10 Jan 2017

Abstract excerpt

Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functionality of therapeutic cassettes delivered by these means and test the flexibility of this approach to clinically relevant alleles. Because CCR5-negative T cells are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 28345004
DOI: 10.1016/j.omtm.2016.12.008

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