Article
A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Feb 2018
Skorecki Karl L, Lee Jessica H, Langefeld Carl D, Rosset Saharon, Tzur Shay, Wasser Walter G, Shemer Revital, Hawkins Gregory A, Divers Jasmin, Parekh Rulan S, Li Man, Sampson Matthew G, Kretzler Matthias, Pollak Martin R, Shah Shrijal, Blackler Daniel, Nichols Brendan, Wilmot Michael, Alper Seth L, Freedman Barry I, Friedman David J
Abstract excerpt
Background: Inheritance of apolipoprotein L1 gene (APOL1) renal-risk variants in a recessive pattern strongly associates with non-diabetic end-stage kidney disease (ESKD). Further evidence supports risk modifiers in APOL1-associated nephropathy; some studies demonstrate that heterozygotes possess excess risk for ESKD or show earlier age at ESKD, relative to those with zero risk alleles. Nearby loci are also...
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