Low‐molecular‐weight heparin associated with reduced fetal fraction and subsequent false‐negative cell‐free DNA test result for trisomy 21

Abstract excerpt

Cell-free DNA (cfDNA) testing for fetal trisomies 21, 18 and 13 is now widely used in clinical practice; however, false-positives and -negatives do occur1, 2. Reasons for false-positives have been well documented and include vanishing twin syndrome, genetic chimerism caused by blood transfusion or maternal malignancy, and confined placental mosaicism3, whilst reasons for false-negatives are much less well known....

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