Article
Effects of Trough Concentration and Solute Carrier Polymorphisms on Imatinib Efficacy in Chinese Patients with Chronic Myeloid Leukemia.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques - 1 Jan 2020
Wang Qing, Jiang Zhi-Ping, Zeng Jing, Zhu Yan, Cai Hua-Lin, Xiang Da-Xiong, He Qun, Shi Xiao-Liu, Zhong An-Ni, Zhao Xie-Lan, Xu Ping
Abstract excerpt
PURPOSE: We investigated the relationship between imatinib trough concentrations and genetic polymorphisms with efficacy of imatinib in Chinese patients with chronic myeloid leukemia (CML). METHODS: There were 171 eligible patients. Peripheral blood samples were collected from 171 eligible patients between 21 and 27 hours after the last imatinib administration. Complete cytogenetic response (CCyR), major...
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