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Article

The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme.

Scientific reports - 23 Mar 2017

Torraca Vincenzo, Tulotta Claudia, Snaar-Jagalska B Ewa, Meijer Annemarie H

Abstract excerpt

CXC chemokine receptor 4 plays a critical role in chemotaxis and leukocyte differentiation. Furthermore, there is increasing evidence that links this receptor to angiogenesis. Using the well-established zebrafish-Mycobacterium marinum model for tuberculosis, angiogenesis was recently found to be important for the development of cellular aggregates called granulomas that contain the mycobacteria and are the...

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Source

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Identifiers

PMID: 28332618
DOI: 10.1038/srep45061
PMCID: PMC5362882

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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