Sequencing of sporadic Attention-Deficit Hyperactivity Disorder (ADHD) identifies novel and potentially pathogenic de novo variants and excludes overlap with genes associated with autism spectrum disorder.

doi:10.1002/ajmg.b.32527

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Article

Sequencing of sporadic Attention-Deficit Hyperactivity Disorder (ADHD) identifies novel and potentially pathogenic de novo variants and excludes overlap with genes associated with autism spectrum disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2017

Kim Daniel Seung, Burt Amber A, Ranchalis Jane E, Wilmot Beth, Smith Joshua D, Patterson Karynne E, Coe Bradley P, Li Yatong K, Bamshad Michael J, Nikolas Molly, Eichler Evan E, Swanson James M, Nigg Joel T, Nickerson Deborah A, Jarvik Gail P

Abstract excerpt

Attention-Deficit Hyperactivity Disorder (ADHD) has high heritability; however, studies of common variation account for <5% of ADHD variance. Using data from affected participants without a family history of ADHD, we sought to identify de novo variants that could account for sporadic ADHD. Considering a total of 128 families, two analyses were conducted in parallel: first, in 11 unaffected parent/affected proband...

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PMID: 28332277
DOI: 10.1002/ajmg.b.32527
PMCID: PMC5467442

Genes

CSMD2
DAGLA
MIP
TRPM2

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