Article
Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD.
Science translational medicine - 10 Aug 2011
Lionel Anath C, Crosbie Jennifer, Barbosa Nicole, Goodale Tara, Thiruvahindrapuram Bhooma, Rickaby Jessica, Gazzellone Matthew, Carson Andrew R, Howe Jennifer L, Wang Zhuozhi, Wei John, Stewart Alexandre F R, Roberts Robert, McPherson Ruth, Fiebig Andreas, Franke Andre, Schreiber Stefan, Zwaigenbaum Lonnie, Fernandez Bridget A, Roberts Wendy, Arnold Paul D, Szatmari Peter, Marshall Christian R, Schachar Russell, Scherer Stephen W
Abstract excerpt
Attention deficit hyperactivity disorder (ADHD) is a common and persistent condition characterized by developmentally atypical and impairing inattention, hyperactivity, and impulsiveness. We identified de novo and rare copy number variations (CNVs) in 248 unrelated ADHD patients using million-feature genotyping arrays. We found de novo CNVs in 3 of 173 (1.7%) ADHD patients for whom we had DNA from both parents....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.