Cynomolgus monkeys are successfully and persistently infected with hepatitis E virus genotype 3 (HEV-3) after long-term immunosuppressive therapy.

doi:10.1371/journal.pone.0174070

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Article

Cynomolgus monkeys are successfully and persistently infected with hepatitis E virus genotype 3 (HEV-3) after long-term immunosuppressive therapy.

PloS one - 1 Jan 2017

Gardinali Noemi Rovaris, Guimarães Juliana Rodrigues, Melgaço Juliana Gil, Kevorkian Yohan Britto, Bottino Fernanda de Oliveira, Vieira Yasmine Rangel, da Silva Aline Campos de Azevedo, Pinto Douglas Pereira, da Fonseca Laís Bastos, Vilhena Leandro Schiavo, Uiechi Edilson, da Silva Maria Cristina Carlan, Moran Julio, Marchevsky Renato Sérgio, Cruz Oswaldo Gonçalves, Otonel Rodrigo Alejandro Arellano, Alfieri Amauri Alcindo, de Oliveira Jaqueline Mendes, Gaspar Ana Maria Coimbra, Pinto Marcelo Alves

Abstract excerpt

Epidemiological studies found that hepatitis E virus genotype 3 (HEV-3) infection was associated with chronic hepatitis and cirrhosis in immunocompromised patients. Our study aimed to investigate the relationship between the host immunosuppressive status and the occurrence of HEV-related chronic hepatitis. Here we describe a successful experimental study, using cynomolgus monkeys previously treated with...

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PMID: 28328941
DOI: 10.1371/journal.pone.0174070
PMCID: PMC5362194

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