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Article

CRISPR-Cas9–guided oncogenic chromosomal translocations with conditional fusion protein expression in human mesenchymal cells

21 Mar 2017

Abstract excerpt

Significance Fusion genes resulting from recurrent chromosomal translocations are associated with several tumor types. Cell lines carrying translocations represent important models to study the oncogenic properties of fusion proteins and develop therapeutic strategies. The desmoplastic small round cell tumor is a rare sarcoma characterized by translocation between the EWSR1 and WT1 genes, resulting in expression...

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PMID: 28325870
DOI: 10.1073/pnas.1700622114

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