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Article

MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE

18 Mar 2017

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex disease targeting multiple organs as a result of overactivation of the type I interferon (IFN) system, a feature currently being targeted by multiple biologic therapies against IFN-α. We have identified an estrogen-regulated microRNA, miR-302d, whose expression is decreased in SLE patient monocytes and identify its target as interferon regulatory factor (IRF)-9, a...

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PMID: 28318807
DOI: 10.1016/j.jaut.2017.03.003

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