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Article

Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii.

The Journal of biological chemistry - 28 Apr 2017

Kong Pengfei, Ufermann Christoph-Martin, Zimmermann Diana L M, Yin Qing, Suo Xun, Helms J Bernd, Brouwers Jos F, Gupta Nishith

Abstract excerpt

Toxoplasma gondii is among the most prevalent protozoan parasites, which infects a wide range of organisms, including one-third of the human population. Its rapid intracellular replication within a vacuole requires efficient synthesis of glycerophospholipids. Cytidine diphosphate-diacylglycerol (CDP-DAG) serves as a major precursor for phospholipid synthesis. Given the peculiarities of lipid biogenesis,...

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Identifiers

PMID: 28314772
DOI: 10.1074/jbc.M116.765487
PMCID: PMC5409480

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Source receipt: pubmed, retrieved 7 Sept 2026.

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