Article
Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii.
The Journal of biological chemistry - 28 Apr 2017
Kong Pengfei, Ufermann Christoph-Martin, Zimmermann Diana L M, Yin Qing, Suo Xun, Helms J Bernd, Brouwers Jos F, Gupta Nishith
Abstract excerpt
Toxoplasma gondii is among the most prevalent protozoan parasites, which infects a wide range of organisms, including one-third of the human population. Its rapid intracellular replication within a vacuole requires efficient synthesis of glycerophospholipids. Cytidine diphosphate-diacylglycerol (CDP-DAG) serves as a major precursor for phospholipid synthesis. Given the peculiarities of lipid biogenesis,...
Topics
- Animals
- Animals, Genetically Modified
- Apicoplasts
- Diacylglycerol Cholinephosphotransferase
- Endoplasmic Reticulum
- Fibroblasts
- Fluorescent Antibody Technique, Indirect
- Gene Deletion
- Glycerophospholipids