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Article

Phosphatidylthreonine and Lipid-Mediated Control of Parasite Virulence.

PLoS biology - 1 Jan 2015

Arroyo-Olarte Ruben D, Brouwers Jos F, Kuchipudi Arunakar, Helms J Bernd, Biswas Aindrila, Dunay Ildiko R, Lucius Richard, Gupta Nishith

Abstract excerpt

The major membrane phospholipid classes, described thus far, include phosphatidylcholine (PtdCho), phosphatidylethanolamine (PtdEtn), phosphatidylserine (PtdSer), and phosphatidylinositol (PtdIns). Here, we demonstrate the natural occurrence and genetic origin of an exclusive and rather abundant lipid, phosphatidylthreonine (PtdThr), in a common eukaryotic model parasite, Toxoplasma gondii. The parasite expresses...

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Identifiers

PMID: 26565995
DOI: 10.1371/journal.pbio.1002288
PMCID: PMC4643901

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PTS

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