Article
Identification of the binding sites for ubiquinone and inhibitors in the Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae by photoaffinity labeling.
The Journal of biological chemistry - 12 May 2017
Ito Takeshi, Murai Masatoshi, Ninokura Satoshi, Kitazumi Yuki, Mezic Katherine G, Cress Brady F, Koffas Mattheos A G, Morgan Joel E, Barquera Blanca, Miyoshi Hideto
Abstract excerpt
The Na+-pumping NADH-quinone oxidoreductase (Na+-NQR) is the first enzyme of the respiratory chain and the main ion transporter in many marine and pathogenic bacteria, including Vibrio cholerae The V. cholerae Na+-NQR has been extensively studied, but its binding sites for ubiquinone and inhibitors remain controversial. Here, using a photoreactive ubiquinone PUQ-3 as well as two aurachin-type inhibitors...
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