Article
Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.
The Journal of biological chemistry - 15 Apr 2005
Bertero Michela G, Rothery Richard A, Boroumand Nasim, Palak Monica, Blasco Francis, Ginet Nicolas, Weiner Joel H, Strynadka Natalie C J
Abstract excerpt
The crystal structure of Escherichia coli nitrate reductase A (NarGHI) in complex with pentachlorophenol has been determined to 2.0 A of resolution. We have shown that pentachlorophenol is a potent inhibitor of quinol:nitrate oxidoreductase activity and that it also perturbs the EPR spectrum of one of the hemes located in the membrane anchoring subunit (NarI). This new structural information together with...
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