Article
Quantitative Contribution of rs75017182 to Dihydropyrimidine Dehydrogenase mRNA Splicing and Enzyme Activity.
Clinical pharmacology and therapeutics - 1 Oct 2017
Nie Q, Shrestha S, Tapper E E, Trogstad-Isaacson C S, Bouchonville K J, Lee A M, Wu R, Jerde C R, Wang Z, Kubica P A, Offer S M, Diasio R B
Abstract excerpt
Dihydropyrimidine dehydrogenase (DPD; DPYD gene) variants have emerged as reliable predictors of adverse toxicity to the chemotherapy agent 5-fluorouracil (5-FU). The intronic DPYD variant rs75017182 has been recently suggested to promote alternative splicing of DPYD. However, both the extent of alternative splicing and the true contribution of rs75017182 to DPD function remain unclear. In the present study we...
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