Article
Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders.
Molecular psychiatry - 1 May 2018
Devanna P, Chen X S, Ho J, Gajewski D, Smith S D, Gialluisi A, Francks C, Fisher S E, Newbury D F, Vernes S C
Abstract excerpt
Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their prevalence and potential severity for quality of life. While large-scale genomic screens have made major advances in this area, for many disorders the genetic underpinnings are complex and poorly understood. To date the field has focused predominantly on protein coding variation, but...
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