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Article

Next-generation DNA sequencing identifies novel gene variants and pathways involved in specific language impairment.

Scientific reports - 25 Apr 2017

Chen Xiaowei Sylvia, Reader Rose H, Hoischen Alexander, Veltman Joris A, Simpson Nuala H, Francks Clyde, Newbury Dianne F, Fisher Simon E

Abstract excerpt

A significant proportion of children have unexplained problems acquiring proficient linguistic skills despite adequate intelligence and opportunity. Developmental language disorders are highly heritable with substantial societal impact. Molecular studies have begun to identify candidate loci, but much of the underlying genetic architecture remains undetermined. We performed whole-exome sequencing of 43 unrelated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28440294
DOI: 10.1038/srep46105
PMCID: PMC5404330

Genes

AUTS2
ERC1
OXR1
STARD9
SYNPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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