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Article

TLR4 gene polymorphism associated with lifetime cigarette smoking in bipolar disorder.

Journal of neuroimmunology - 15 Apr 2017

Zerdazi El-Hadi, Oliveira José, Vorspan Florence, Bennabi Meriem, Jamain Stéphane, Etain Bruno, Leboyer Marion, Tamouza Ryad, Bellivier Frank

Abstract excerpt

Bipolar disorder (BD) is associated with an increased risk of tobacco dependence, the leading addictive substance worldwide. Toll-like receptor 4, a sensor of pathogens and of products of cellular stress and damage, is a major innate immune molecule and logical candidate gene for tobacco dependence in BD because (i) the involvement of TLR4 molecules in several substance use disorders has been suggested, (ii) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28284355
DOI: 10.1016/j.jneuroim.2017.01.021

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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