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Article

A zebrafish model for HAX1-associated congenital neutropenia.

Haematologica - 1 May 2021

Doll Larissa, Aghaallaei Narges, Dick Advaita M, Welte Karl, Skokowa Julia, Bajoghli Baubak

Abstract excerpt

Severe congenital neutropenia (CN) is a rare heterogeneous group of diseases, characterized by a granulocytic maturation arrest. Autosomal recessive mutations in the HAX1 gene are frequently detected in affected individuals. However, the precise role of HAX1 during neutrophil differentiation is poorly understood. To date, no reliable animal model has been established to study HAX1-associated CN. Here we show that...

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Identifiers

PMID: 32327498
DOI: 10.3324/haematol.2019.240200
PMCID: PMC8094079

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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