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Article

Elevated glycemia and brain glucose utilization predict BDNF lowering since early life.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Mar 2018

Guzzardi Maria Angela, Sanguinetti Elena, Bartoli Antonietta, Kemeny Alessandra, Panetta Daniele, Salvadori Piero A, Burchielli Silvia, Iozzo Patricia

Abstract excerpt

Obesity and diabetes associate with neurodegeneration. Brain glucose and BDNF are fundamental in perinatal development. BDNF is related to brain health, food intake and glucose metabolism. We characterized the relationship between glycemia and/or brain glucose utilization (by 18FDG-PET during fasting and glucose loading), obesity and BDNF in 4-weeks old (pre-obese) and 12-weeks old (obese) Zucker fa/fa rats, and...

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Source

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Identifiers

PMID: 28281382
DOI: 10.1177/0271678X17697338
PMCID: PMC5851134

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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