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Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

22 Oct 2019

Abstract excerpt

Metabolic diseases harm brain health and cognitive functions, but whether maternal metabolic unbalance may affect brain plasticity of next generations is still unclear. Here, we demonstrate that maternal high fat diet (HFD)-dependent insulin resistance multigenerationally impairs synaptic plasticity, learning and memory. HFD downregulates BDNF and insulin signaling in maternal tissues and epigenetically inhibits...

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PMID: 31641124
DOI: 10.1038/s41467-019-12793-3

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