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Article

Single-Stranded DNA Library Preparation Preferentially Enriches Short Maternal DNA in Maternal Plasma

28 Apr 2017

Abstract excerpt

BACKGROUND: Recent studies have suggested that single-stranded DNA (ssDNA) library preparation can enrich short DNA species from the plasma of healthy individuals, cancer patients, and transplant recipients. Based on previous observations that fetal DNA molecules in the maternal plasma are shorter than maternal DNA molecules, ssDNA library preparation may potentially enrich fetal DNA and provide substantial...

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PMID: 28280050
DOI: 10.1373/clinchem.2016.268656

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