Article
Targeted massively parallel sequencing of maternal plasma DNA permits efficient and unbiased detection of fetal alleles.
Clinical chemistry - 1 Jan 2011
Liao Gary J W, Lun Fiona M F, Zheng Yama W L, Chan K C Allen, Leung Tak Y, Lau Tze K, Chiu Rossa W K, Lo Y M Dennis
Abstract excerpt
BACKGROUND: Massively parallel sequencing has recently been used in noninvasive prenatal diagnosis. The current costs of this technology are still relatively expensive, however, and sample throughput is still relatively low when it is used as a molecular diagnostic tool. Rather than nonselectively sequencing the genome, target enrichment provides a logical approach for more efficient and cost-effective massively...
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