Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology.

Experimental dermatology - 1 Mar 2013

Melnik Bodo C, Plewig Gerd

Abstract excerpt

Recent findings in familial hidradenitis suppurativa (HS) demonstrated loss-of-function mutations of components of the γ-secretase (GS) complex leading to decreased protease cleaving activity, which may compromise canonical Notch signalling. Appropriate Notch signalling is of pivotal importance for maintaining the inner and outer root sheath of the hair follicle and skin appendages. This viewpoint on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid Precursor Protein Secretases
Share to Hidradenitis Suppurativa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunity, Innate

Share to Interleukin-1beta

Share to Receptors, Notch

Share to Th17 Cells

Share to Translational Research, Biomedical

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 23489419
DOI: 10.1111/exd.12098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired Notch-MKP-1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology.PMID 23489419Read ↗

Insights from γ-Secretase: Functional Genetics of Hidradenitis Suppurativa.Semantic proximity Read ↗

Unravelling the complex pathogenesis of hidradenitis suppurativa.Semantic proximity Read ↗

Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the DiseaseSemantic proximity Read ↗

Hidradenitis Suppurativa: Comprehensive Review of Predisposing Genetic Mutations and ChangesSemantic proximity Read ↗

A systematic review and critical evaluation of reported pathogenic sequence variants in hidradenitis suppurativa.Semantic proximity Read ↗

The impact of innate immunity and epigenetics in the pathogenesis of hidradenitis suppurativaSemantic proximity Read ↗

γ-Secretase Genetics of Hidradenitis Suppurativa: A Systematic Literature Review.Semantic proximity Read ↗

Hidradenitis suppurativa: Detangling phenotypes and identifying common denominators.Semantic proximity Read ↗

Hormonal, stem cell and Notch signalling as possible mechanisms of disease in hidradenitis suppurativa: a systems‐level transcriptomic analysisSemantic proximity Read ↗

Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic SignalingSemantic proximity Read ↗

Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophagesSemantic proximity Read ↗

γ-Secretase mutations in hidradenitis suppurativa: new insights into disease pathogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.