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Vps33b regulates Vwf‐positive vesicular trafficking in megakaryocytes

20 Jun 2016

Abstract excerpt

Mutations of vacuolar protein sorting-associated protein 33b (VPS33B) cause arthrogryposis, renal dysfunction, and cholestasis syndrome, and a lack of platelet α-granules in the affected patients. Conditional Vps33b knockout mice were developed to investigate the function(s) of Vps33b in platelet α-granule formation. We found that early embryonic deletion of Vps33b was lethal. PF4-Cre-driven...

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PMID: 27319744
DOI: 10.1002/path.4762

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