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mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

7 Mar 2017

Abstract excerpt

The ovary contains oocytes within immature (primordial) follicles that are fixed in number at birth. Activation of follicles within this fixed pool causes an irreversible decline in reproductive capacity, known as the ovarian reserve, until menopause. Premenopausal women undergoing commonly used genotoxic (DNA-damaging) chemotherapy experience an accelerated loss of the ovarian reserve, leading to subfertility...

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Share to Ovarian cancer diagnosis and treatment
Share to PI3K/AKT/mTOR signaling in cancer
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PMID: 28270607
DOI: 10.1073/pnas.1617233114

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