Article
Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy.
BMC evolutionary biology - 7 Mar 2017
Cuypers Lize, Vrancken Bram, Fabeni Lavinia, Marascio Nadia, Cento Valeria, Di Maio Velia Chiara, Aragri Marianna, Pineda-Peña Andrea Clemencia, Schrooten Yoeri, Van Laethem Kristel, Balog Daniel, Focà Alfredo, Torti Carlo, Nevens Frederik, Perno Carlo Federico, Vandamme Anne-Mieke, Ceccherini-Silberstein Francesca
Abstract excerpt
BACKGROUND: In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.