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Article

Phylodynamic Analysis and Implication of HCV Genotype 4 Variability on Antiviral Drug Response and T-Cell Recognition.

Viruses - 28 Nov 2020

Colomba Giuseppina Maria Elena, Urone Noemi, Marco Vito di, Ferraro Donatella

Abstract excerpt

Therapies for HCV care could change the prevalence and the geographic distribution of genotypes due to differences in Sustained Virologic Response (SVR). In this scenario, uncommon genotypes/subtypes, such as genotype 4, could spread from high-risk groups, replacing genotypes eradicated by antiviral drugs. Genotype eradication is also strongly influenced by the CD8+ T cell response. In this study, the genetic...

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Identifiers

PMID: 33260596
DOI: 10.3390/v12121363
PMCID: PMC7761199

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