Article
Genetic 3'UTR variation is associated with human pigmentation characteristics and sensitivity to sunlight.
Experimental dermatology - 1 Oct 2017
Hernando Barbara, Peña-Chilet Maria, Ibarrola-Villava Maider, Martin-Gonzalez Manuel, Gomez-Fernandez Cristina, Ribas Gloria, Martinez-Cadenas Conrado
Abstract excerpt
Sunlight exposure induces signalling pathways leading to the activation of melanin synthesis and tanning response. MicroRNAs (miRNAs) can regulate the expression of genes involved in pigmentation pathways by binding to the complementary sequence in their 3'untranslated regions (3'UTRs). Therefore, 3'UTR SNPs are predicted to modify the ability of miRNAs to target genes, resulting in differential gene expression....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.