Article
Effects of RET, NRG1 and NRG3 Polymorphisms in a Chinese Population with Hirschsprung Disease.
Scientific reports - 3 Mar 2017
Yang Dehua, Yang Jun, Li Shuai, Jiang Meng, Cao Guoqing, Yang Li, Zhang Xi, Zhou Ying, Li Kang, Tang Shao-Tao
Abstract excerpt
The RET proto-oncogene was identified as a major locus involved in Hirschsprung disease (HSCR). A genome-wide association study (GWAS) and whole exome sequencing identified NRG1 and NRG3 as additional HSCR susceptibility loci. We investigated the effects of RET (rs2506030 and rs2435357), NRG1 (rs2439302, rs16879552 and rs7835688) and NRG3 (, and ) polymorphisms in a Chinese...