Article
Evaluation of von Willebrand factor phenotypes and genotypes in Hemophilia A patients with and without identified F8 mutations.
Journal of thrombosis and haemostasis : JTH - 1 Jun 2015
Boylan B, Rice A S, De Staercke C, Eyster M E, Yaish H M, Knoll C M, Bean C J, Miller C H
Abstract excerpt
BACKGROUND: Hemophilia A (HA) is an X-linked bleeding disorder caused by a deficiency in factor VIII (FVIII). von Willebrand disease (VWD) is characterized by a quantitative or qualitative defect in von Willebrand factor (VWF). Patients with VWD with severely low VWF or VWD Type 2N (VWD2N), a VWD subtype distinguished by defective VWF binding to FVIII, may have reduced FVIII levels secondary to their VWD. These...
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