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Article

Chloroquine triggers Epstein-Barr virus replication through phosphorylation of KAP1/TRIM28 in Burkitt lymphoma cells

1 Mar 2017

Abstract excerpt

Trials to reintroduce chloroquine into regions of Africa where P. falciparum has regained susceptibility to chloroquine are underway.However, there are long-standing concerns about whether chloroquine increases lytic-replication of Epstein-Barr virus (EBV), thereby contributing to the development of endemic Burkitt lymphoma.We report that chloroquine indeed drives EBV replication by linking the DNA repair...

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PMID: 28249048
DOI: 10.1371/journal.ppat.1006249

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