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Expansion of a Lepidopteran Carboxylesterase Gene Cluster Drives Xanthotoxin Detoxification in Spodoptera litura

19 May 2025

Abstract excerpt

In plant–insect coevolution, xanthotoxin serves as a widespread phytochemical defense against herbivores. This study aims to elucidate xanthotoxin detoxification mechanisms in the polyphagous pest Spodoptera litura . Genomic analyses revealed an expanded carboxylesterase (COE) cluster on chromosome 2, exhibiting xanthotoxin-inducible expression in detoxification tissues. Knockdown of ten COEs significantly...

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PMID: 40388639
DOI: 10.1021/acs.jafc.5c02804

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