Article
An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition.
Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2007
Eleftherianos Ioannis, Boundy Sam, Joyce Susan A, Aslam Shazia, Marshall James W, Cox Russell J, Simpson Thomas J, Clarke David J, ffrench-Constant Richard H, Reynolds Stuart E
Abstract excerpt
Photorhabdus is a virulent pathogen that kills its insect host by overcoming immune responses. The bacterium also secretes a range of antibiotics to suppress the growth of other invading microorganisms. Here we show that Photorhabdus produces a small-molecule antibiotic (E)-1,3-dihydroxy-2-(isopropyl)-5-(2-phenylethenyl)benzene (ST) that also acts as an inhibitor of phenoloxidase (PO) in the insect host Manduca...
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