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Article

Aberrant splicing in maize rough endosperm3 reveals a conserved role for U12 splicing in eukaryotic multicellular development.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017

Gault Christine M, Martin Federico, Mei Wenbin, Bai Fang, Black Joseph B, Barbazuk W Brad, Settles A Mark

Abstract excerpt

RNA splicing of U12-type introns functions in human cell differentiation, but it is not known whether this class of introns has a similar role in plants. The maize ROUGH ENDOSPERM3 (RGH3) protein is orthologous to the human splicing factor, ZRSR2. ZRSR2 mutations are associated with myelodysplastic syndrome (MDS) and cause U12 splicing defects. Maize rgh3 mutants have aberrant endosperm cell differentiation and...

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Identifiers

PMID: 28242684
DOI: 10.1073/pnas.1616173114
PMCID: PMC5358371

Genes

ZRSR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Aberrant splicing in maize rough endosperm3 reveals a conserved role for U12 splicing in eukaryotic multicellular development.PMID 28242684Read ↗

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