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Article

Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials

24 Feb 2017

Abstract excerpt

Past clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach to PD: A single-mechanism therapy can affect most of those sharing the classic pathological hallmark. From a systems-biology perspective, PD is a group of...

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PMID: 28233927
DOI: 10.1002/mds.26913

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