Article
KIR/HLA-I mismatching and risk of relapse in paediatric patients undergoing non-haploidentical allogeneic haematopoietic stem cell transplantation.
Pediatric transplantation - 1 Mar 2011
Scquizzato Elisa, Zambello Renato, Teramo Antonella, Baesso Ilenia, Varotto Stefania, Albergoni Maria Paola, Boscaro Elisa, Cesaro Simone, Pillon Marta, Calore Elisabetta, Gazzola Maria Vittoria, Semenzato Gianpietro, Messina Chiara, Trentin Livio
Abstract excerpt
In HSCT setting, KIR-driven alloreactivity might be better predicted if the donor KIR genotype is considered in addition to the recipient HLA genotype. The prediction of NK cell alloreactivity relies on the missing ligand in the recipient, a scenario that can be found in HLA-identical and non-identical allotransplants. The aim of this study was to investigate at genetic level the prognostic impact of recipient...
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