Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment.

International journal of molecular sciences - 14 Feb 2017

Vernot Jean-Paul, Bonilla Ximena, Rodriguez-Pardo Viviana, Vanegas Natalia-Del Pilar

Abstract excerpt

An understanding of the cell interactions occurring in the leukemic microenvironment and their functional consequences for the different cell players has therapeutic relevance. By co-culturing mesenchymal stem cells (MSC) with the REH acute lymphocytic leukemia (ALL) cell line, we have established an in vitro leukemic niche for the functional evaluation of hematopoietic stem/progenitor cells (HSPC, CD34+ cells)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Cell Communication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coculture Techniques

Share to Leukemia

Share to Lymph Nodes

Share to Mesenchymal Stem Cells

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Stem Cell Niche

Source

Open in PubMed Open full text

Identifiers

PMID: 28216566
DOI: 10.3390/ijms18020199
PMCID: PMC5343770

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment.PMID 28216566Read ↗

LW/SO cell line: a tool for studying the phenotypical characterization and commitment of hematopoietic stem cells.Semantic proximity Read ↗

Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: correlations with the course of disease.Semantic proximity Read ↗

Phenotypic and functional comparison of mesenchymal stem cells derived from the bone marrow of normal adults and patients with hematologic malignant diseases.Semantic proximity Read ↗

Intrinsic Growth Deficiencies of Mesenchymal Stromal Cells in Myelodysplastic SyndromesSemantic proximity Read ↗

Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34− cell population with intrinsic resistance to imatinibSemantic proximity Read ↗

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid LeukaemiaSemantic proximity Read ↗

[Phenotypic shift in blast cells of acute lymphoblastic leukemia during recurrence: biological and clinical implications].Semantic proximity Read ↗

Targeting the leukemia microenvironment.Semantic proximity Read ↗

Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia.Semantic proximity Read ↗

Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.Semantic proximity Read ↗

Severe Hypoxia Defines Heterogeneity and Selects Highly Immature Progenitors Within Clonal Erythroleukemia CellsSemantic proximity Read ↗

Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.