Article
Targeting LSCs through membrane antigens selectively or preferentially expressed on these cells.
Blood cells, molecules & diseases - 1 Dec 2015
Pelosi Elvira, Castelli Germana, Testa Ugo
Abstract excerpt
Studies of xenotransplantation of bone marrow and blood cells of AML patients have supported the existence of rare leukemic stem cells, able to initiate and maintain the leukemic process and bearing the typical leukemic abnormalities. LSCs possess self-renewal capacity and are responsible for the growth of the more differentiated leukemic progeny in the bone marrow and in the blood. These cells are more resistant...
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