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Article

Converting S-limonene synthase to pinene or phellandrene synthases reveals the plasticity of the active site.

Phytochemistry - 1 May 2017

Xu Jinkun, Ai Ying, Wang Jianhui, Xu Jingwei, Zhang Yongkang, Yang Dong

Abstract excerpt

S-limonene synthase is a model monoterpene synthase that cyclizes geranyl pyrophosphate (GPP) to form S-limonene. It is a relatively specific enzyme as the majority of its products are composed of limonene. In this study, we converted it to pinene or phellandrene synthases after introducing N345A/L423A/S454A or N345I mutations. Further studies on N345 suggest the polarity of this residue plays a critical role in...

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PMID: 28215610
DOI: 10.1016/j.phytochem.2017.02.017

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