Article
Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA.
Oncotarget - 25 Apr 2017
Kluzek Katarzyna, Srebniak Malgorzata I, Majer Weronika, Ida Agnieszka, Milecki Tomasz, Huminska Kinga, van der Helm Robert M, Silesian Adrian, Wrzesinski Tomasz M, Wojciechowicz Jacek, Beverloo Berna H, Kwias Zbigniew, Bluyssen Hans A R, Wesoly Joanna
Abstract excerpt
BACKGROUND: Mutation analysis and cytogenetic testing in clear cell renal cell carcinoma (ccRCC) is not yet implemented in a routine diagnostics of ccRCC. MATERIAL AND METHODS: We characterized the chromosomal alterations in 83 ccRCC tumors from Polish patients using whole genome SNP genotyping assay. Moreover, the utility of next generation sequencing of cell free DNA (cfDNA) in patients plasma as a potential...
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