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Article

Targeting Angiogenesis in Biliary Tract Cancers: An Open Option.

International journal of molecular sciences - 15 Feb 2017

Simone Valeria, Brunetti Oronzo, Lupo Luigi, Testini Mario, Maiorano Eugenio, Simone Michele, Longo Vito, Rolfo Christian, Peeters Marc, Scarpa Aldo, Azzariti Amalia, Russo Antonio, Ribatti Domenico, Silvestris Nicola

Abstract excerpt

Biliary tract cancers (BTCs) are characterized by a bad prognosis and the armamentarium of drugs for their treatment is very poor. Although the inflammatory status of biliary tract represents the first step in the cancerogenesis, the microenvironment also plays a key role in the pathogenesis of BTCs, promoting tumor angiogenesis, invasion and metastasis. Several molecules, such as vascular endothelial growth...

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Identifiers

PMID: 28212293
DOI: 10.3390/ijms18020418
PMCID: PMC5343952

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