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Article

The enteric nervous system promotes intestinal health by constraining microbiota composition.

PLoS biology - 1 Feb 2017

Rolig Annah S, Mittge Erika K, Ganz Julia, Troll Josh V, Melancon Ellie, Wiles Travis J, Alligood Kristin, Stephens W Zac, Eisen Judith S, Guillemin Karen

Abstract excerpt

Sustaining a balanced intestinal microbial community is critical for maintaining intestinal health and preventing chronic inflammation. The gut is a highly dynamic environment, subject to periodic waves of peristaltic activity. We hypothesized that this dynamic environment is a prerequisite for a balanced microbial community and that the enteric nervous system (ENS), a chief regulator of physiological processes...

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Identifiers

PMID: 28207737
DOI: 10.1371/journal.pbio.2000689
PMCID: PMC5331947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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