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Article

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord.

Scientific reports - 13 Feb 2017

Hilton James B, Mercer Stephen W, Lim Nastasia K H, Faux Noel G, Buncic Gojko, Beckman Joseph S, Roberts Blaine R, Donnelly Paul S, White Anthony R, Crouch Peter J

Abstract excerpt

Ubiquitous expression of mutant Cu/Zn-superoxide dismutase (SOD1) selectively affects motor neurons in the central nervous system (CNS), causing the adult-onset degenerative disease amyotrophic lateral sclerosis (ALS). The CNS-specific impact of ubiquitous mutant SOD1 expression is recapitulated in transgenic mouse models of the disease. Here we present outcomes for the metallo-complex CuII(atsm) tested for...

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Source

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Identifiers

PMID: 28205575
DOI: 10.1038/srep42292
PMCID: PMC5304223

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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