Article
Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing.
Oncotarget - 14 Mar 2017
Youssef Omar, Knuuttila Aija, Piirilä Päivi, Böhling Tom, Sarhadi Virinder, Knuutila Sakari
Abstract excerpt
Exhaled breath condensate (EBC) is a non-invasive source that can be used for studying different genetic alterations occurring in lung tissue. However, the low yield of DNA available from EBC has hampered the more detailed mutation analysis by conventional methods. We applied the more sensitive amplicon-based next generation sequencing (NGS) to identify cancer related mutations in DNA isolated from EBC. In order...
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